منابع مشابه
Decoding human regulatory circuits.
Clusters of transcription factor binding sites (TFBSs) which direct gene expression constitute cis-regulatory modules (CRMs). We present a novel algorithm, based on Gibbs sampling, which locates, de novo, the cis features of these CRMs, their component TFBSs, and the properties of their spatial distribution. The algorithm finds 69% of experimentally reported TFBSs and 85% of the CRMs in a refer...
متن کاملDecoding action intentions in parietofrontal circuits.
Michael Vesia1,2* and Marco Davare3* 1Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre, Toronto, Canada, 2Department of Kinesiology and Faculty of Applied Health Sciences, University of Waterloo, Waterloo, Ontario, Canada M4V 3M5, and 3Sobel Department of Motor Neurosciences and Motor Disorders, Institute of Neurology, University College London, Queen Sq...
متن کاملDepression: Abnormality in Neural Circuits
Depression as a kind of mental illness affects huge number of population worldwide and is ranked as the fourth leading cause of disability worldwide, and is predicted to increase to the second place by 2020. Depression leads to great social burden because of its substantial impairment and disability in everyday activities. Though great efforts in previous decades have been made to understand th...
متن کاملMental state decoding abilities in clinical depression.
BACKGROUND Depression is associated with profound impairments in social functioning. Past research and theory suggests that these impairments may be related to a difficulty in the ability of depressed individuals to identify and decode others' social cues. However, the nature of this difficulty is equivocal. This investigation is the first to adopt a theory-of-mind framework to examine unipolar...
متن کاملToward decoding the principles of cancer metastasis circuits.
Understanding epithelial-mesenchymal transitions (EMT) during cancer metastasis remains a major challenge in modern biology. Recent observations of cell behavior together with progress in mapping the underlying regulatory genetic networks led to new understandings of carcinoma metastasis. It is now established that the genetic network that regulates the EMT also enables an epithelial-mesenchyma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.336.6089.1620-d